Familial form of sick sinus syndrome. New views on polygenic origin and prospects for gene therapy

Iskenderov B.G.

ABSTRACT

This review article presents the new data on the polygenic origin of the familial (congenital) form of sick sinus syndrome (SSS) and the approaches to gene therapy of this pathology. We also provide information concerning the epidemiology of SSS and the acquired (secondary) causes of SSS. The article presents detailed characteristics of the main genes associated with the development of SSS and the mechanisms of ion channel disorders responsible for arrhythmogenesis. Genetic and phenotypic variants associated with the development and clinical course of familial SSS are also described. We also present the latest achievements in the field of SSS gene therapy and prospects for its development.

Key words: sick sinus syndrome, sudden cardiac death, cardiac arrhythmias, pacemaker, gene therapy.

For citation:

Iskenderov B.G. Familial form of sick sinus syndrome. New views on polygenic origin and prospects for gene therapy. International Journal of Heart and Vascular Diseases. 2023. 11(37). 4-14. doi: 10.24412/2311-1623-2023-37-5-16